Table 1. Variation of the VP1 amino acid sequences among the EV71 genotype A strains.
| EV71 strains | Residue variation in VP1 protein | |||||||||
| 1 | 2 | 3 | 14 | 18 | 22 | 30 | 31 | 47 | 60 | |
| EV71/BrCr/USA/1970 | G | D | R | D | K | P | P | D | L | D |
| EV71/CMU33-1/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | - | - |
| EV71/CMU3-1/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | - | - |
| EV71/CMU47-1/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | - | - |
| EV71/CMU48-1/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | - | - |
| EV71/001-Luan/AH/CHN/2008 | - | - | - | - | - | Q | Q | N | - | - |
| EV71/1401-Luan/AH/CHN/2008 | - | G | - | E | - | Q | Q | N | - | - |
| EV71/1404-Luan/AH/CHN/2008 | - | G | - | R | R | Q | Q | N | - | Y |
| EV71/1901-Luan/AH/CHN/2008 | R | G | Q | - | - | Q | Q | N | - | - |
| E V71/1906-Luan/AH/CHN/2008 | - | - | - | - | - | Q | Q | N | - | - |
| EV71/CMU1-2/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | P | - |
| EV71/CMU21-2/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | P | - |
| EV71/CMU28-2/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | P | - |
| EV71/CMU46-1/BJ/CHN/2009 | - | - | - | - | - | Q | Q | N | P | - |
| EV71/Hubei/HuB/CHN/2009 | - | - | - | - | - | Q | Q | N | - | - |
In total, there were 297 amino acids in the VP1 protein of EV71, and 26 residue variations were found in the VP1 amino acid sequence among EV71 genotype A viruses. The 8 amino acid substitutions conserved across all genotype A strains excluding BrCr are marked with bold letters.
Identical = –.