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. 2013 Feb 13;8(2):e56162. doi: 10.1371/journal.pone.0056162

Figure 4. PBOV1 expression in breast cancer and proneural glioma is correlated to a positive clinical outcome of the disease.

Figure 4

A. Kaplan-Meier analysis of a pooled dataset of breast cancer expression profiles from six independent clinical studies [34] shows that higher levels of PBOV1 expression positively correlated to relapse-free survival in breast cancer. Among clinical subgroups the effect was mostly pronounced in cases of lymph node positive cancers and in cases of grade 2 tumors (data obtained from GOBO online tool [34]). B. PBOV1 expression levels in clinical samples of estrogen receptor-positive breast cancer positively correlate to the patient relapse-free survival over 5 years following tamoxifen therapy (data obtained from GEO dataset GDS806 [35]). Error bars represent standard error of the mean. C. PBOV1 expression levels in clinical tumor samples from proneural glioma patients positively correlate with survival over 209 weeks (data obtained from GEO dataset GDS1816 [36]). Error bars represent standard error of the mean. D. Primary proneural gliomas have significantly higher expression levels of PBOV1 expression than recurrent ones (data obtained from GEO dataset GDS1816 [36]). Error bars represent standard error of the mean.