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. 2013 Feb 13;8(2):e56491. doi: 10.1371/journal.pone.0056491

Figure 2. Bacterial internalization is decreased in DMOG treated cells.

Figure 2

To mimic hypoxia, A549 cells were pre-treated with 1 mM of the pan-hydroxylase inhibitor DMOG or its' solvent DMSO for 24 h and throughout following infection with the P. aeruginosa reference strain ATCC 27853 (A), a CF pathogen B. cenocepacia, J2315 (B) and two clinical P. aeruginosa isolates from CF patients, S7587, mucoid and non-mucoid P. aeruginosa (C and D). Data represent mean ± SEM of 3 independent experiments throughout (* p<0.05; *** p<0.0001).