Figure 3. [¹¹C]PK11195 and [¹⁸F]DPA-714 mean uptake values between 20 and 60 min post-injection (expressed as percentage of injected dose per cm³, mean±SD (A) and Core/contralateral ROIs ratio (B)) of the 7 animals scanned with both tracers successively within 24 h (2 animals with no lesion are not shown on these graphs, although there exclusion did not affect the outcome of the statistical analysis).

* Significantly different from [¹¹C]PK11195 values, # significantly different from the contralateral side of the same tracer (Wilcoxon paired test, p<0.05). (C) Correlation between [¹¹C]PK11195 and [¹⁸F]DPA-714 core/contralateral ROIs ratio (all animals included) (dotted line = 95% confidence interval). (D) On the left of each panel, PET images shown are summed images between 20 and 60 min after injection of [¹¹C]PK11195 (left panel) and [¹⁸F]DPA-714 (right panel) co-registered with the MRI template. The ROIs automatically segmented from the corresponding PET images are shown on the right part of each panel. The ROIs are: infarct core (red; ROI covering the infarct in the MCAO territory and/or with the highest uptake), edge-1 (orange; ROI around the MCAO territory and/or with the 2^nd highest uptake), edge-2 (yellow; ROI around the MCAO territory and/or with the 3^rd highest uptake), contralateral ROI (green; ROI with the lowest uptake) and skull edges (white; 5^th ROI segmented in some animals, located on the edge of the skull, this ROI was not included in the statistical analysis).