Table 2. Meta-analysis data source.
Name | Study title | PMID [Ref] | GEO/ArrayExpress accession numbers | N | CD | UC | CDU | UCU | Platform |
Ahr | Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. | 18981162 [21] | GSE10191 | 11 | 0 | 8 | 0 | 0 | Affymetrix HG-U133 Plus 2.0 |
Ari | Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment | 19956723 [20] | GSE16879 | 6 | 19 | 24 | 0 | 0 | Affymetrix HG-U133 Plus 2.0 |
Bje | Genome-wide gene expression analysis of mucosal colonic biopsies and isolated colonocytes suggests a continuous inflammatory state in the lamina propria of patients with quiescent ulcerative colitis | 19834973 [22] | GSE13367 | 10 | 0 | 8 | 0 | 9 | Affymetrix HG-U133 Plus 2.0 |
Car | Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease. | 18069684 [17] | GSE9686 | 8 | 10 | 5 | 0 | 0 | Affymetrix HG-U133 Plus 2.0 |
Gal | Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results | 18843029 [23] | GSE10714 | 3 | 8 | 3 | 0 | 0 | Affymetrix HG-U133 Plus 2.0 |
Gyo | Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature | 18776587 [16] | GSE4183 | 8 | 6 | 9 | 0 | 0 | Affymetrix HG-U133 Plus 2.0 |
Kug | Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease | 18758464 [24] | GSE10616 | 11 | 32 | 10 | 0 | 0 | Affymetrix HG-U133 Plus 2.0 |
Nob | Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis | 18523026 [13] | GSE11223 | 63 | 0 | 62 | 0 | 61 | Agilent Whole Human Genome microarray |
Ols | Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data | 19177426 [11] | GSE9452 (UC samples) and GSE11831 (controls), E-TABM-118 (CD samples) | 17 | 0 | 8 | 0 | 9 | Affymetrix HG-U133 Plus 2.0 |
vbG | NTNU study | E-MTAB-184 | 20 | 8 | 37 | 19 | 44 | Illumina human HT-12 expression BeadChips | |
Wu | Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. | 17262812 [10] | GSE6731 | 4 | 7 | 5 | 12 | 4 | Affymetrix HG -U95Av2 |
Information on all data sets used in meta-analysis. Column “Name” refers to abbreviations used in Figure 2- and Figure S1–S5. “Study title” refers to name of original source article, with reference given in column “PMID [Ref]”. Column “No. samples” gives number of samples in each group in the relevant data set, with the following group names: N – Normal controls, CD – Crohn’s disease, UC – Ulcerative colitis, CDU – Un-inflamed Crohn’s disease and UCU – Un-inflamed ulcerative colitis. Column “Platform” refers to microarray technology used in the relevant analysis.