Table 2. Pregnancy and delivery characteristics in women with and without a child with epilepsy.
Characteristic | With epilepsy | Without epilepsy | p value |
0.7% (n = 302) | (n = 43,087) | ||
Mean maternal age±SD (year) | 29.6±5.7 | 29.0±5.5 | 0.04 |
Mean number of previous pregnancies | 1.6±1.9 | 1.5±1.6 | 0.13 |
Mean number of previous deliveries | 1.2±1.5 | 1.0±1.3 | 0.14 |
Primiparous women | 35.8 | 40.9 | 0.07 |
Multiparous women | 64.2 | 59.1 | |
Pregravid BMI±SD | 23.2±4.3 | 23.3±4.7 | 0.65 |
Mean weight increase±SD (kg) | 12.9±5.1 | 13.5±5.3 | 0.05 |
Mode of delivery | |||
Vaginal | 67.2 | 77.2 | ≤0.001 |
Vacuum | 4.6 | 6.0 | |
CS, total | 28.2 | 16.8 | |
CS, elective | 11.6 | 7.7 | |
CS, non-elective | 16.6 | 9.1 | |
Mean gestational age at birth±SD (weeks) | 38.8±3.1 | 39.3±2.1 | 0.19 |
≤27 | 2.0 | 0.5 | ≤0.001 |
28−31 | 2.7 | 0.7 | |
32−36 | 5.8 | 4.7 | |
37−40 | 67.8 | 69.8 | |
41−42 | 21.0 | 23.9 | |
≥43 | 0.7 | 0.3 | |
Epidural analgesia in vaginal deliveries | 26.2 | 36.7 | 0.002 |
Placental abruption | 2.0 | 0.6 | 0.003 |
Preeclampsia | 4.3 | 3.8 | 0.63 |
Elevated liver enzymes | 0.0 | 0.8 | 0.12 |
ART | 1.1 | 0.7 | 0.02 |
Of which IVF | 0.7 | 0.7 | 0.91 |
Maternal bleeding during pregnancy | 2.4 | 1.6 | 0.35 |
Amnionitis | 1.7 | 1.1 | 0.31 |
Maternal epilepsy | 3.3 | 0.8 | ≤0.001 |
Maternal smoking | |||
Before pregnancy | 16.3 | 24.6 | 0.18 |
During pregnancy | 12.2 | 11.9 | 0.94 |
Maternal anemia | |||
First trimester | 0.3 | 0.2 | 0.59 |
Second trimester | 0.7 | 0.8 | 0.75 |
Third trimester | 1.3 | 1.0 | 0.53 |
Maternal hypertension | 2.6 | 2.0 | 0.39 |
Umbilical cord insertion | |||
Central | 83.3 | 80.4 | 0.24 |
Marginal | 14.0 | 17.5 | |
Velamentous | 2.7 | 2.1 | |
Mean umbilical cord length±SD (cm) | 55.7±12.0 | 58.7±13.0 | ≤0.001 |
Lowest 5%, ≤38 | 7.9 | 4.1 | 0.001 |
39−43 | 6.3 | 5.8 | |
44−74 | 79.5 | 78.4 | |
75−81 | 4.6 | 6.6 | |
Longest 5%, ≥82 | 1.7 | 5.2 |
BMI = body mass index, CS = Cesarean section, ART = assisted reproductive technology.