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. 2013 Feb 13;8(2):e55394. doi: 10.1371/journal.pone.0055394

Table 2. Pregnancy and delivery characteristics in women with and without a child with epilepsy.

Characteristic With epilepsy Without epilepsy p value
0.7% (n = 302) (n = 43,087)
Mean maternal age±SD (year) 29.6±5.7 29.0±5.5 0.04
Mean number of previous pregnancies 1.6±1.9 1.5±1.6 0.13
Mean number of previous deliveries 1.2±1.5 1.0±1.3 0.14
Primiparous women 35.8 40.9 0.07
Multiparous women 64.2 59.1
Pregravid BMI±SD 23.2±4.3 23.3±4.7 0.65
Mean weight increase±SD (kg) 12.9±5.1 13.5±5.3 0.05
Mode of delivery
Vaginal 67.2 77.2 ≤0.001
Vacuum 4.6 6.0
CS, total 28.2 16.8
 CS, elective 11.6 7.7
 CS, non-elective 16.6 9.1
Mean gestational age at birth±SD (weeks) 38.8±3.1 39.3±2.1 0.19
≤27 2.0 0.5 ≤0.001
28−31 2.7 0.7
32−36 5.8 4.7
37−40 67.8 69.8
41−42 21.0 23.9
≥43 0.7 0.3
Epidural analgesia in vaginal deliveries 26.2 36.7 0.002
Placental abruption 2.0 0.6 0.003
Preeclampsia 4.3 3.8 0.63
Elevated liver enzymes 0.0 0.8 0.12
ART 1.1 0.7 0.02
Of which IVF 0.7 0.7 0.91
Maternal bleeding during pregnancy 2.4 1.6 0.35
Amnionitis 1.7 1.1 0.31
Maternal epilepsy 3.3 0.8 ≤0.001
Maternal smoking
Before pregnancy 16.3 24.6 0.18
During pregnancy 12.2 11.9 0.94
Maternal anemia
First trimester 0.3 0.2 0.59
Second trimester 0.7 0.8 0.75
Third trimester 1.3 1.0 0.53
Maternal hypertension 2.6 2.0 0.39
Umbilical cord insertion
Central 83.3 80.4 0.24
Marginal 14.0 17.5
Velamentous 2.7 2.1
Mean umbilical cord length±SD (cm) 55.7±12.0 58.7±13.0 ≤0.001
Lowest 5%, ≤38 7.9 4.1 0.001
39−43 6.3 5.8
44−74 79.5 78.4
75−81 4.6 6.6
Longest 5%, ≥82 1.7 5.2

BMI = body mass index, CS = Cesarean section, ART = assisted reproductive technology.