Table 1. The clinical evaluation of EAE mice.

Group	n	Incidence ( % )	Mean onset date	Mean score of maximal symptom
EAE control	13	100	12.38±1.45	2.62±1.08
Fasudil late	13	76.9	13.50±2.17	1.41±1.08*
Fasudil early	13	23.1*	18.00±3.61*	0.30±0.72**

Fasudil was injected (i.p.) at 40 mg/kg/d every other day on day 3 p.i. (Fasudil early treatment) and on day 11 p.i. (Fasudil late treatment). The injection of normal saline was set up as control (EAE control) in a similar manner. Data are presented as mean ± S.E.M.

^* p<0.05,

^** p<0.01.