Table 2. Patients divided into tertiles according to serum levels of 25(OH)D.
| Tertiles of 25(OH)D | ||||||||
| Range: 22–47 nmol/L (n = 17) | Range: 47–65 nmol/L (n = 18) | Range: 67–115 nmol/L (n = 17) | p-value | |||||
| Females (%)a | 13 | (76.5) | 16 | (88.9) | 13 | (76.5) | 0.56 | |
| Age | 55.9 | (14.7) | 61.4 | (11.3) | 64.9 | (10.8) | 0.038 | |
| BMI (kg/m2) | 28.0 | (4.12) | 26.1 | (3.47) | 24.9 | (4.47) | 0.013b | |
| 1,25(OH)2D (pmol/L) | 151 | (124–205) | 138 | (122–198) | 172 | (146–193) | 0.32c | |
| PTH (pmol/L) | 15.0 | (8.55–23.4) | 12.8 | (9.55–18.9) | 12.7 | (10.4–16.6) | 0.28c | |
| iCa (mmol/L) | 1.52 | (0.09) | 1.47 | (0.09) | 1.44 | (0.09) | 0.069c | |
| Phosphate (mmol/L) | 0.81 | (0.15) | 0.90 | (0.20) | 0.80 | (0.13) | 0.23c | |
| eGFR (mL/min/1.73 m2) | 91.7 | (19.8) | 83.0 | (22.4) | 77.4 | (22.9) | 0.096c | |
| ALP (U/L) | 94.0 | (75.5–124) | 89.0 | (68.5–108) | 86.0 | (72.5–114) | 0.35c | |
| BMD radius (g/cm2) | 0.50 | (0.11) | 0.46 | (0.11) | 0.45 | (0.10) | 0.55d | |
| BMD lumbal spine (g/cm2) | 1.12 | (0.17) | 1.03 | (0.19) | 1.06 | 0.19) | 0.42d | |
| BMD femural neck (g/cm2) | 0.86 | (0.13) | 0.77 | (0.12) | 0.79 | (0.10) | 0.62d | |
Values are given as mean (standard deviation) or median (25th–75th percentile). PTH, 1,25(OH)2D and ALP were log-transformed before used in the analyses. BMI, body mass index; PHPT, primary hyperparathyroidism; PTH, parathyroid hormone; iCa, ionised calcium; APL, alkaline phosphatase; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)2D, 1,25-dihydroxyvitamin D; eGFR, estimated glomerular filtration rate; BMD, bone mineral density. P-values for linear trend over tertiles.
a
Values are numbers (percentages), differences across tertiles are assessed with a chi-square test.
b
Age was used as covariate.
c
Age and BMI were used as covariates.
d
Age, BMI and gender were used as covariates.