Table 3. Patients divided into tertiles according to serum levels of 1,25(OH)2D.
| Tertiles of 1,25(OH)2D | |||||||||
| Range: 48–137 pmol/L n = 17 | Range: 138–176 pmol/L n = 18 | Range: 179–350 pmol/L n = 17 | p-value | ||||||
| Females (%)a | 13 | (76.4) | 14 | (77.8) | 15 | (88.2) | 0.63 | ||
| Age | 60.5 | (12.3) | 61.1 | (10.6) | 60.6 | (15.5) | 0.99 | ||
| BMI (kg/m2) | 26.1 | (3.66) | 26.8 | (5.09) | 26.2 | (3.79) | 0.96 | ||
| 25(OH)D (nmol/L) | 47.7 | (15.7) | 67.6 | (21.2) | 58.6 | (23.2) | 0.14 | ||
| PTH (pmol/L) | 11.4 | (8.70–15.2) | 11.2 | (8.60–14.1) | 18.2 | (12.5–24.8) | 0.011 | ||
| iCa (mmol/L) | 1.48 | (0.09) | 1.46 | (0.08) | 1.51 | (0.10) | 0.29 | ||
| Phosphate (mmol/L) | 0.90 | (0.17) | 0.83 | (0.13) | 0.80 | (0.18) | 0.062 | ||
| eGFR (mL/min/1.73 m2) | 76.8 | (21.3) | 81.9 | (20.7) | 93.3 | (22.3) | 0.029 | ||
| ALP (U/L) | 80.0 | (70.0–97.0) | 99.0 | (73.3–124) | 89.0 | (79.5–125) | 0.30 | ||
| BMD radius (g/cm2) | 0.48 | (0.11) | 0.50 | (0.80) | 0.41 | (0.11) | 0.002d | ||
| BMD lumbal spine (g/cm2) | 1.04 | (0.19) | 1.09 | (0.15) | 1.07 | (0.22) | 0.66d | ||
| BMD femural neck (g/cm2) | 0.77 | (0.12) | 0.82 | (0.10) | 0.82 | (0.14) | 0.11d | ||
Values are given as mean (standard deviation) or median (25th–75th percentile). PTH, 1,25(OH)2D and ALP were log-transformed before used in the analyses. BMI, body mass index; PHPT, primary hyperparathyroidism; PTH, parathyroid hormone; iCa, ionised calcium; APL, alkaline phosphatase; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)2D, 1,25-dihydroxyvitamin D; eGFR, estimated glomerular filtration rate; BMD, bone mineral density. P-values for linear trend over tertiles.
a
Values are numbers (percentages), differences across tertiles are assessed with a chi-square test.
d
Age, BMI and gender were used as covariates.