Table 6. Relations between the genotype variations of the SNPs studied and bone mineral density in lumbar spine, femoral neck and distal radius.

rs number		Genotype					Bone mineral density (g/cm2)
					Frequency n (%)	Radius			Lumbar spine			Femoral neck
VDR
rs1544410		GG	19 (37)			0.48 (0.09)			1.14 (0.17)			0.85 (0.13)
		GA	26 (50)			0.46 (0.12)			1.03 (0.19)			0.79 (0.12)
		AA	7 (13)			0.46 (0.08)			1.00 (0.16)			0.72 (0.07)
p-value1						0.39			0.046			0.036
p-value2						0.88			0.41			0.065
rs7975232		CC	11 (21)			0.50 (0.08)			1.21 (0.16)			0.87 (0.12)
		CA	31 (61)			0.47 (0.12)			1.04 (0.17)			0.80 (0.13)
		AA	9 (18)			0.44 (0.10)			1.01 (0.19)			0.74 (0.09)
p-value1						0.21			0.003			0.032
p-value2						0.79			0.47			0.26
rs2228570		CC	18 (35)			0.47 (0.10)			1.05 (0.16)			0.80 (0.10)
		CT	27 (52)			0.47 (0.11)			1.07 (0.21)			0.81 (0.15)
		TT	7 (13)			0.48 (0.10)			1.10 (0.16)			0.79 (0.09)
p-value1						0.35			0.49			0.95
p-value2						0.87			0.57			0.70
25-hydroxylase (Cyp2R1)
rs10741657		GG	23 (44)			0.49 (0.11)			1.09 (0.17)			0.81 (0.13)
		GA	18 (35)			0.48 (0.10)			1.11 (0.21)			0.83 (0.14)
		AA	11 (21)			0.42 (0.10)			0.95 (0.12)			0.75 (0.08)
p-value1						0.10			0.38			0.84
p-value2						0.145			0.039			0.25
24-hydroxylase (Cyp24a1)
rs6013897	TT			19 (36)		0.50 (0.10)		1.15 (0.16)			0.82 (0.11)
	TA			29 (56)		0.46 (0.10)				1.02 (0.18)			0.80 (0.11)
	AA			4 (8)		0.42 (0.14)				1.03 (0.23)			0.78 (0.27)
p-value1						0.26				0.018			0.83
p-value2						0.40				0.83			0.86
rs2762939	GG			24 (46)		0.48 (0.10)				1.05 (0.17)			0.80 (0.10)
	GC			25 (48)		0.47 (0.11)				1.08 (0.21)			0.83 (0.14)
	CC			3 (6)		0.42 (0.10)				1.04 (0.07)			0.67 (0.03)
p-value1						0.74				0.57			0.60
p-value2						0.52				0.99			0.13
1-alfa hydroxylase (Cyp27B1)
rs10877012	GG			27 (53)		0.46 (0.11)				1.09 (0.19)			0.79 (0.11)
	GT			18 (35)		0.47 (0.10)				1.03 (0.17)			0.82 (0.14)
	TT			6 (12)		0.49 (0.07)				1.05 (0.19)			0.80 (0.12)
p-value1						0.77				0.24			0.95
p-value2						0.52				0.97			0.46

SNP, single nucleotide polymorphism; VDR, vitamin D receptor.

¹p-values are based on linear regression with age, gender and body mass index as covariates. Minor allele considered as dominant.

²p-values are based on linear regression with age, gender and body mass index as covariates. Minor allele considered as recessive. After Bonferroni-correction a p-value <0.007 is considered to be statistically significant.