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. Author manuscript; available in PMC: 2013 Feb 13.
Published in final edited form as: Adv Drug Deliv Rev. 2007 Mar 16;59(2-3):141–152. doi: 10.1016/j.addr.2007.03.008

Figure 1.

Figure 1

(A) Diagram of a super-coiled expression plasmid DNA encapsulated in an 85 nm pegylated immunoliposome targeted to a cell membrane receptor (R) with a receptor-specific, endocytosing monoclonal antibody (MAb). Tissue-specific expression of the plasmid is regulated by the promoter (pro), which is inserted 5′ of the gene. (B) Transmission electron microscopy of a PIL. The MAb molecule tethered to the tips of the 2000-Dalton polyethylene glycol (PEG) is bound by a conjugate of 10 nm gold and a secondary antibody. The position of the gold particles shows the relationship of the PEG extended MAb and the liposome. Magnification bar = 20 nm. From [20].