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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Clin Neurosci. 2012 Apr 18;19(6):875–880. doi: 10.1016/j.jocn.2011.12.016

Fig. 6.

Fig. 6

Post-injection imaging of super-paramagnetic iron oxide (Fe3O4) nanoparticle (SPION)-Ad5/3 cRGD and saline. Nanoparticle-labeled Ad5/3-cRGD-green fluorescent protein (GFP) was injected into subcortical white matter of a pig and contralateral saline injection was used as a control. (A) Axial (upper) T2-weighted MRI showing greater T2-weighted hyperintense area around the site of virus compared to saline injection that persists for up to 72 hours; and (lower) gradient echo (GRE) showing hypointensity at the virus site, and a smaller area of hypointensity on the saline-infused side. (B) The volume of T2 hyperintensity is greater with virus injection (gray) compared to saline injection (black) as measured by both T2-weighted and GRE signal.