Table.
The pharmacodynamic and pharmacokinetic parameters (mean±SEM) with and without the InsuPatch activation after the same bolus dose of aspart insulin investigated by euglycemic clamp study.
| Pharmacodynamic Parameters | No InsuPatch | With InsuPatch | P |
|---|---|---|---|
| GIRmax (mg/kg/min) | 7.2±0.7 | 8.0±1 | 0.4 |
| T GIRmax (min) | 125±8 | 90±6 | 0.002 |
| T 50%GIRmax (min) | 58±5 | 40±3 | 0.01 |
| AUC GIR 0-300min (mg/kg) | 1141±107 | 1280±118 | 0.1 |
| AUC GIR 0-90min (mg/kg) | 260±30 | 354±40 | 0.001 |
| Pharmacokinetic Parameters* | P | ||
| ΔCins (uU/mL) | 32±3 | 45±7 | 0.08 |
| ΔCmax (uU/mL) | 81±8 | 106±11 | 0.04 |
| AUC ΔCins 0-300 min (uU.min/ml) | 10470±1202 | 13380±1670 | 0.02 |
| AUC ΔCins 0-90 min (uU.min/ml) | 4342±441 | 5846±698 | 0.04 |
*
All values calculated as increments above baseline (ΔC)