Table 4.

Risk factors associated with decreased survival

	Univariate		Multivariate
HR (95%CI)	P	HR (95% CI)	P
Gender (M vs. F)	0.79 (0.32–1.95)	0.61
Age, per 1 year	1.00 (0.95–1.04)	0.86
Primary disease (islet cell vs. carcinoid)	1.21 (0.51–2.89)	0.66	0.67 (0.26–1.71)	0.40
Functional vs. non-functional (islet cell tumour)	0.95 (0.28–3.27)	0.94
Need for repeated RFA	1.31 (0.49–3.50)	0.59
Pre-operative octreotide	0.53 (0.12–2.28)	0.39
Tumour histology
Grade (Grade 2 vs. Grade 1)	2.30 (0.91–5.84)	0.08
Mitoses, per 1 unit	1.02 (0.99–1.05)	0.15
Angioinvasion (Yes vs. No)	2.06 (0.81–5.19)	0.18
Ki67 index (≥3.5 vs. <3.5)	4.28 (1.51–12.14)	0.006	5.01 (1.65–15.18)	0.004
Inflammation (Yes vs. No)	1.57 (0.46–5.38)	0.47

RFA, radiofrequency ablation.