Table 5.

Risk factors associated with decreased symptom-free survival

	Univariate
HR (95%CI)	P
Gender (M vs. F)	1.04 (0.68–1.58)	0.87
Age, per 1 year	0.98 (0.97–1.00)	0.13
Primary disease (islet cell vs. carcinoid)	1.38 (0.91–2.09)	0.13
Functional vs. non-functional (islet cell tumour)	1.19 (0.69–2.06)	0.52
Need for repeated RFA	1.33 (0.83–2.13)	0.24
Preoperative octreotide	1.73 (1.04–2.89)	0.03
Tumour histology
Grade (Grade 2 vs. Grade 1)	1.02 (0.63–1.65)	0.94
Mitoses, per 1 unit	1.01 (0.99–1.02)	0.62
Angioinvasion (Yes vs. No)	1.17 (0.76–1.79)	0.48
Ki67 index (≥ 3.5 vs. < 3.5)	1.53 (0.98–2.38)	0.06
Inflammation (Yes vs. No)	1.52 (0.73–3.19)	0.26

RFA, radiofrequency ablation.