Table 1.
Shown are plasma levels, in micromolar units, of cocaine (A) and benzoic acid (B) observed 5 and 45 min after 3H-cocaine injection (10 mg/kg, i.p.) in mice pretreated with saline, CocH (2 or 4 mg/kg, i.p.), or antibody (AB, 12 mg/kg, s.c.), singly or in combination.
| A Cocaine (μM) | ||||||
|---|---|---|---|---|---|---|
| Saline | CocH 2 mg | CocH 4 mg | AB | AB+ CocH 2 mg | AB + CocH 4 mg | |
| 5-min | ||||||
| n | 5 | 4 | 4 | 5 | 4 | 4 |
| Mean ± SEM | 0.40 ± 0.05 | 0.04 ± 0.00 | 0.02 ± 0.00 | 1.00 ± 0.15 | 0.40 ± 0.04 | 0.06 ± 0.03 |
| 45-min | ||||||
| n | 3 | 3 | 2 | 3 | 3 | 2 |
| Mean ± SEM | 1.60 ± 0.22 | 1.20 ± 0.11 | 0.19 | 3.10 ± 0.79 | 1.20 ± 0.33 | 0.17 |
| B Benzoic acid (μM) | ||||||
|---|---|---|---|---|---|---|
| Saline | CocH 2 mg | CocH 4 mg | AB | AB+ CocH 2 mg | AB + CocH 4 mg | |
| 5-min | ||||||
| n | 5 | 4 | 4 | 5 | 4 | 4 |
| Mean ± SEM | 0.21 ± 0.03 | 6.00 ± 0.53 | 6.20 ± 0.67 | 0.34 ± 0.11 | 2.70 ± 0.47 | 6.00 ± 0.77 |
| 45-min | ||||||
| n | 3 | 3 | 2 | 3 | 3 | 2 |
| Mean ± SEM | 3.70 ± 0.82 | 12.6 ± 1.6 | 14.5 | 3.00 ± 0.29 | 16.0 ± 1.90 | 14.0 |