Table 1.
Psychomotor and cognitive effects
| Dose condition | Circular lights | Divided attention
|
Word recognition
|
Metamemory | ||||
|---|---|---|---|---|---|---|---|---|
| Number completed | Tracking deviation | Proportion correct | Hit rate | False alarm rate | d′ | C | Gamma correlation | |
| Placebo | 102.9 (2.1) | 103.5 (2.8) | 104.1 (3.0) | 0.82 (0.02) | 0.21 (0.03) | 1.87 (0.15) | −0.03 (0.07) | 0.57 (0.05) |
| Ketamine | ||||||||
| 0.2 mg/kg (i.m.) | 94.7 (2.5) | 101.6 (2.2) | 97.2 (3.0) | 0.78 (0.02) | 0.22 (0.03) | 1.66 (0.13) | 0.02 (0.06) | 0.60 (0.05) |
| 0.4 mg/kg (i.m.) | 82.1 (3.0) | 118.4 (4.4) | 85.4 (4.5) | 0.73 (0.04) | 0.26 (0.03) | 1.41 (0.13) | 0.02 (0.11) | 0.59 (0.06) |
| Triazolam | ||||||||
| 0.2 mg/70 kg (p.o.) | 87.8 (2.3)a | 129.7 (5.6)a | 92.1 (2.6) | 0.74 (0.03) | 0.25 (0.04) | 1.53 (0.18) | 0.04 (0.10) | 0.51 (0.07) |
| 0.4 mg/70 kg (p.o.) | 73.2 (2.5)a | 172.1 (9.1) | 79.2 (3.9) | 0.62 (0.03)a | 0.32 (0.04) | 0.91 (0.14)a | 0.13 (0.09) | 0.41 (0.06)a |
Values in bold indicate significant differences from placebo
a
Indicates a significant difference between the low or high doses of ketamine and triazolam, respectively