Fig. 2.

Nonsteroidal anti-inflammatory drugs (NSAIDs) interact directly with the bile salts (BS) and phosphatidylcholine (PC) of pure and mixed micelles, converting the macromolecules into more toxic micelles. It is hypothesized that biliary secretions include nontoxic BS/PC micelles that can interact with secreted indomethacin (Indo) to yield either of the following: 1) toxic mixed micelles or 2) moderately toxic pure bile salt micelles where the PC has been removed to interact with Indo. Furthermore, an additional still another possibility is for that secreted pure bile salt micelles interact with Indo to form, 3) toxic Indo/bile salt micelles devoid of PC.