Table 2.

Association between SNPs and incident CHD and stroke in the Greek-EPIC cohort^*.

SNP	Locus	Gene(s) in region	Weight^**	Alleles risk/other	High-risk allele frequency in controls (n = 1345)	CHD (n = 494)		Stroke (n = 320)
SNP	Locus	Gene(s) in region	Weight^**	Alleles risk/other	High-risk allele frequency in controls (n = 1345)	OR (95% CI)	p-value	OR (95% CI)	p-value
rs11206510	1p32	PCSK9	1.15	T/C	0.79	1.02 (0.85–1.22)	0.836	1.03 (0.83–1.28)	0.799
rs646776	1p13	CELSR2-PSRC1-SORT1	1.19	T/C	0.81	1.10 (0.91–1.33)	0.388	1.16 (0.92–1.47)	0.258
rs17465637	1q41	MIA3	1.14	C/A	0.71	1.09 (0.93–1.29)	0.290	1.13 (0.93–1.38)	0.228
rs6725887	2q33	WDR12	1.17	C/T	0.14	1.26 (1.04–1.54)	0.021	1.00 (0.78–1.28)	0.979
rs12526453	6p24	PHACTR1	1.12	C/G	0.61	1.09 (0.93–1.26)	0.287	1.05 (0.88–1.26)	0.570
rs1333049	9p21	CDKN2A-CDKN2B	1.29	C/G	0.51	1.30 (1.12–1.51)	0.001	1.05 (0.88–1.26)	0.575
rs1746048	10q11	CXCL12	1.17	C/T	0.82	0.95 (0.79–1.15)	0.613	0.89 (0.71–1.11)	0.312
rs1122608	19p13	LDLR	1.15	G/T	0.72	1.05 (0.89–1.24)	0.558	1.12 (0.92–1.36)	0.273
rs9982601	21q22	SLC5A3-MRPS6-KCNE2	1.20	T/C	0.12	1.15 (0.92–1.42)	0.213	0.71 (0.52–0.96)	0.026

Abbreviations: SNP = single nucleotide polymorphism; OR = odds ratio perallele; CI = confidence interval; CHD = coronary heart disease; EPIC = European prospective investigation into cancer and nutrition.

Association tested with unconditional logistic regression adjusted for age and sex.

^**

SNP specific weights used for genetic risk score calculation; weights are effect sizes for the SNPs from Ref. [20] except for rs1333049 at 9p21 for which Ref. [26] was used.