Fig. 5.

The simulated total plasma phenytoin concentrations. a Adults, dose: 18 mg/kg. b Adults, dose: 22.5 mg/kg. c Adults, dose: 30 mg/kg. d Children, dose: 18 mg/kg. e Children, dose: 22.5 mg/kg. f Children, dose: 30 mg/kg; rate, 3 mg/kg/min). Dotted line, individual simulated concentrations using the final model; solid line, 95 percentile or 5 percentile of predicted values using the final model