Table 3.

Parameter estimates from the final population pharmacokinetic model and results of the bootstrap analysis

Parameter		Estimate	Standard error	95% CI	Bootstrap estimate	Bootstrap standard error	Bootstrap 95% CI
Population mean
CL (L/h)a	θ1	1.61	0.0933	1.43–1.79	1.61	0.0878	1.48–1.74
ΘWT (CL)	θ2	0.569	0.0862	0.400–0.738	0.575	0.0912	0.431–0.734
V2 (L)a	θ3	20.8	1.99	16.9–24.7	20.3	2.68	16.1–25.0
Q (L/h)	θ4	53.0	4.75	43.7–62.3	53.4	5.87	44.9–64.1
V3 (L)a	θ5	26.0	1.55	23.0–29.0	26.5	2.43	22.8–30.7
ΘWT (V3)	θ6	0.584	0.0434	0.499–0.669	0.591	0.0520	0.495–0.674
K12 (1/h)	θ7	5.02	0.399	4.24–5.80	4.96	0.518	4.21–6.00
Inter-subject variability
ωCL,CL	ω1,1	0.194	0.0391	0.117–0.271	0.190	0.0348	0.135–0.252
ωV2,V2	ω2,2	0.161	0.0576	0.0481–0.274	0.133	0.0684	0.0164–0.236
ωQ,Q	ω3,3	0.271	0.0840	0.106–0.436	0.289	0.119	0.121–0.494
ωV3,V3	ω4,4	0.0430	0.0167	0.0103–0.0757	0.0470	0.0214	0.0179–0.0900
ωK12,K12	ω5,5	0.106	0.0483	0.0110–0.201	0.112	0.0565	0.0377–0.209
Intra-individual variability
σ2 (exponential error)	σ1,1	0.00148	0.000692	0.000124–0.00284	0.00181	0.00110	0.000495–0.00343
σ2 (additive error)	σ2,2	0.317	0.0977	0.126–0.508	0.304	0.100	0.159–0.473

^aCL, V2, and V3 are typical values for an individual weighing 60 kg