Table 3.
Beclin control of frh-1(RNAi) animals lifespan — summary statistics.
| Genotype | RNAi | Mean lifespan | + SEM | p vs con⁎ | p vs N2⁎ | Sample size (censored)a | N of replicates |
|---|---|---|---|---|---|---|---|
| Wild-type (N2) | con | 18.4 | 0.3 | 212(31) | 3 | ||
| frh-1b | 23.1 | 0.5 | 2.4E − 13 | 212(45) | 3 | ||
| bec-1b | 16.8 | 0.3 | 0.00065 | 140(36) | 2 | ||
| bec-1;frh-1 | 16.7 | 0.3 | 0.82070$ | 4.1E − 24$$ | 140(11) | 2 | |
| bec-1(ok691) | Con | 9.9 | 0.3 | 1.31E − 54 | 70(0) | 1 | |
| frh-1 | 8.4 | 0.4 | 0.02004 | 2.88E − 65 | 70(0) | 1 |
⁎
p-values were calculated using the log-rank test between pooled populations.
$
p-value versus bec-1.
$$
p-value versus frh-1.
a
Pooled worms from N replicate experiments (censored individuals were included in the log rank analysis).
b
Lifespan analyses were performed on worms fed an equal mix of bacteria expressing empty-vector and frh-1 dsRNA or bec-1 dsRNA.