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Schema illustrates the mechanisms of the small molecule sequential dual-targeting anticancer strategy (SMSDTTS): first to treat the solid tumor and to cause massive tumor necrosis by using CA4P. After being iv injected 24h later, 131I-Hyp accumulates in the intratumoural necrosis bordering the viable rim and gradually diffuses into the necrotic center. Diagnostic and therapeutic efficacies are achieved owning to the constant gamma and beta radiation.
