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. 2013 Jan 22;4(2):133–145. doi: 10.7150/jca.5635

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Vascular shutdown effect and subsequent intratumoral necrosis caused by iv injection of CA4P: A. hepatic Rhabdomyosarcoma-1 (R1) tumor in rat was shown on contrast enhanced T1-weighted MR image; B. minutes to hours after CA4P injection, a hypointense tumor is surrounded by a hyperenhanced rim, suggesting vessel shutdown and tumor necrosis with peripheral viable residues; C. the corresponding histological section proves massive intratumoral necrosis (N) and a few layers of viable tumor cells (V) in the periphery adjacent to the normal liver.