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. 2013 Feb 14;4:7. doi: 10.3389/fneur.2013.00007

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Copyright © 2013 den Dunnen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Micrographs of the mesencephalon in Parkinson’s disease (A–C), mutiple system atrophy (D) and progressive supranuclear palsy (E–G). (A) Shows an H&E staining of the substantia nigra with neuronal degeneration and phagocytosis of neuromelanin (arrows). (B) Shows a neuron with two classical Lewy bodies. (C) Shows alfa-synuclein staining with positive staining of a Lewy body (long arrow) and Lewy neuritis (short arrows). MSA is also an alfa-synucleinopathy (D) with both neuronal (long arrow) and oligodendroglial (short arrows) inclusions. (E) Shows a neuron in PSP with a filamentous basophilic inclusion (H&E staining). (F,G) Show immunohistochemical stainings for hyperphosphorylated tau-protein (AT8 clone) with inclusions in a neuron and “tufted” astrocyte respectively.