Table 1.

Odds ratio estimation to assess the association between breast cancer (BC) and DNA repair capacity (DRC) and other selected variables in women with BC (n=285) and women without BC (n=539)

Variable	Women with BC n (mean)	Women without BC n (mean)	Crude OR1	Adjusted OR2	Pvalue
			(95% CI)	(95% CI)
Age (continuous)*	285 (56.7)	539 (52.4)	1.02 (1.02,1.04)	1.02 (1.01, 1.05)	0.001
Number of children	273(2.4)	517 (2.1)	1.2 (1.1, 1.3)	1.1 (1.0, 1.3)	0.055
# Missing (34)
Increasing BMI (continuous)*	284 (27.8)	534 (27.2)	1.02 (0.9, 1.1)	1.03 (1.0, 1.1)	0.118
# Missing (6)
Family history of BC
Yes	64	78	1.7 (1.2, 2.5)	1.7 (1.0, 2.8)	0.054
No	221	461
Marital status
Married	154	362	Referent	Referent
Single	61	92	4.2 (2.2, 7.8)	5.9 (2.3, 15.6)	<0.001
Divorced	40	66	2.7 (1.4, 5.3)	3.6 (1.2, 10.5)	0.025
Widow	30	17	2.9 (1.4, 5.9)	4.6 (1.6, 13.7)	0.006
# Missing (2)
Irregular menstrual cycles
Yes	183	320	1.2 (0.9,1.6)	1.4 (0.8, 2.2)	0.207
No	102	213
# Missing (6)
History of pregnancy
Yes	220	401	1.2 (0.8,1.6)	1.4 (0.8,2.2)	0.382
No	65	138
History of breastfeeding
Yes	122	246	0.8 (0.6, 1.1)	0.8 (0.5, 1.2)	0.256
No	118	194
# Missing (144)
Alcohol intake
Yes	42	98	0.8 (0.6, 1.2)	0.8 (0.5, 1.7)	0.526
No	243	441
Smoking
Yes	37	48	1.6 (0.9, 2.4)	1.1 (0.6, 2.1)	0.707
No	248	491

*Mean values presented in parenthesis.

Comparisons were measured with the crude¹ and the adjusted² multiple logistic regression odds ratio (OR)³ in the total sample divided by patients and women without breast cancer.

¹Crude or unadjusted analysis: The analysis is carried out without taking into consideration potential confounders.

²Adjusted analysis: The analysis is carried out adjusting for the potential effect of all confounding variables simultaneously by using logistic regression model. The associations were adjusted by DRC, age, body mass index, family history of breast cancer, number of children, marital status, and/or smoking.