Table 2.
DNA Repair Capacity (DRC) of women with breast cancer (BC) and women without BC by age group
|
Variable |
Women with BC n (mean DRC) |
Women without BC n (mean DRC) |
Crude OR1 |
Adjusted OR2 |
Pvalue |
|---|---|---|---|---|---|
| (95% CI) | (95% CI) | ||||
| Decreasing DRC (continuous)* |
285 (2.41) |
539 (6.13) |
2.2 (1.9, 2.4) |
2.3 (2.0, 2.6) |
< 0.001 |
| DRC | |||||
| Low (< 4.3%) |
246 |
168 |
13.9 (9.4, 20.4) |
15.1 (10.0, 22.9) |
< 0.001 |
| High (≥ 4.3%) |
39 |
371 |
|
|
|
| DRC levels3 | |||||
| Low (0.0-3.0%) |
213 |
66 |
54.6 (30.3, 98.5) |
60.6 (32.1, 114.6) |
< 0.001 |
| Medium (3.01-5.8%) |
57 |
219 |
4.4 (2.4, 8.0) |
13.0 (8.5, 20.0) |
< 0.001 |
| High (≥5.81%) | 15 | 254 | Referent | Referent | |
*Mean values presented in parenthesis.
Comparisons were measured with the crude1 and the adjusted2 multiple logistic regression odds ratio (OR) in the total sample divided by patients and women without breast cancer.
1Crude or unadjusted analysis: The analysis is carried out without taking into consideration potential confounders.
2Adjusted analysis: The analysis is carried out adjusting for the potential effect of all confounding variables simultaneously by using logistic regression model.
3Chi-Square for linear trend = 233.6, p< 0.001.