Table 1. Effects of MDPV and Comparison Test Drugs on Transporter-Mediated Uptake and Release in Rat Brain Synaptosomes.
| MDPV | Cocaine | Amphetamine | Mephedrone | Methylone | |
|---|---|---|---|---|---|
| DAT uptake IC50 (nℳ±s.e.m.) | 4.1±0.5 | 211±19 | 93±17 | 762±79 | 1232±133 |
| aNET uptake IC50 (nℳ±s.e.m.) | 26±8 | 292±34 | 67±16 | 487±66 | 1031±162 |
| SERT uptake IC50 (nℳ±s.e.m.) | 3349±305 | 313±17 | 3418±314 | 422±26 | 1017±59 |
| DAT release EC50 (nℳ±s.e.m.) | 2.3±0.8 | 151±35 | 5.8±0.4 | 51±5 | 117±12 |
| (Emax %) | (24±1) | (29±1) | (102±1) | (102±2) | (96±1) |
| aNET release EC50 (nℳ±s.e.m.) | 13±16 | 2190±883 | 6.6±0.7 | 58±11 | 140±17 |
| (Emax %) | (24±6) | (34±6) | (92±1) | (99±4) | (94±2) |
| aSERT release EC50 (nℳ±s.e.m.) | Inactive | Inactive | 698±71 | 122±10 | 234±35 |
| (Emax %) | (97±2) | (101±1) | (98±2) |
a
N=4, all other values N=3.