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. 2012 Nov 7;38(4):585–595. doi: 10.1038/npp.2012.216

Figure 6.

Figure 6

Behavioral specificity of adrenergic antagonist treatment in the mPFC during CUS. Performance on each task of the AST preceding the ED set-shifting task is shown in experiment 3. In this experiment, as in experiment 2 (not shown), CUS induced a deficit on the R1 reversal learning task (*p<0.001), which was not prevented by chronic adrenergic antagonist treatment in the mPFC during CUS (p>0.43). Note that in experiment 3, but not experiment 2 (nor in previous studies), CUS had a very modest effect on the SD task (*p<0.03), which also was not affected by chronic adrenergic antagonist treatment in the mPFC (p>0.98). The lack of effect on other components of the AST confirms the behavioral specificity of drug treatment in the mPFC on ED set-shifting. All data are expressed as mean±SEM, n=18–21/group.