Figure 5.

Dose-dependent effects of PRE-084 on extracellular levels of dopamine in the nucleus accumbens shell. Ordinates: extracellular dopamine levels as a percentage of baseline during the 30-min period of time after cumulative drug administration. Abscissae: dose of drug in mg/kg, log scale. Each point represents the mean effect ±SEM determined in four rats. The average basal dopamine values in 10 μl samples of dialysates from the nucleus accumbens shell were 16.2 ±1.46 fmoles (±SEM) and 29.7±2.79 for rats, respectively, with and without cocaine experience, which did not significantly differ in the two groups (t=−2.12; p=0.08).