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Effects of simvastatin (Sim) and dexamethasone (Dex) on IRF3 phosphorylation in bronchial epithelial cells from COPD donors. dsRNA increased phosphorylation of IRF3 (A,B) without changing IRF3 levels (B). Dexamethasone was without significant effects (A,B) whereas simvastatin inhibited phosphorylation of IRF3 (A,B). Data are presented as median ± IQR (n = 6). **P < 0.01. A representative Western blot is shown (B).
