Figure 4.

Effects of baicalein on hippocampal dependent cognitive function. (A–B) MWM probe trials were performed to evaluate spatial learning and memory. Latency times (A) and total distances swum (B) were analysed in mice treated with controls or baicalein with or without radiation treatment. (C) In the passive avoidance test, significant intergroup differences were found in terms of the time taken to enter the dark compartment. In particular, latencies were significantly greater for irradiated mice. Data shown are means ± SEs (n = 5 mice per group). *P < 0.05 versus controls, #P < 0.05, ##P < 0.01 versus 5 Gy irradiated mice (anova using Fisher's PLSD procedure).