Figure 3.

Dose-dependent and antigen-specific blood concentration–time profile and tissue distribution of [¹¹¹In]-anti-TENB2-MMAE (ADC) in non-tumour-bearing SCID mice at 72 h after i.v. injection. The tracer was administered alone (red), in combination with unconjugated anti-TENB2 (ThioMab) at 1 (blue) or 10 (black) mg·kg⁻¹, or in combination with 10 mg·kg⁻¹ of an isotype-matched control antibody, anti-STEAP1 (green). (A) Whole blood PK data, plotted on a linear scale in a dose-normalized manner as % of injected dose mL^-1 of blood, derived by gamma counting in tissue distribution studies. (B) Tissue distribution of [¹¹¹In]-anti-TENB2-MMAE (ADC) in male SCID mice at 72 h expressed as mean %ID g⁻¹ ± SEM for three mice per group. Asterisks indicate statistical significance (P < 0.05) by one-way anova followed by Tukey post-test.