Figure 8.

Comparative disposition of ¹²⁵I- and ¹¹¹In-labelled anti-TENB2-MMAE in the LuCaP 77 tumour explant model with and without a blocking dose of anti-TENB2. Dual-label tracers were co-administered at 0.1 mg·kg⁻¹. Blood concentration–time profiles of anti-TENB2-MMAE labelled with ¹²⁵I (A) and ¹¹¹In (B) were obtained in mice (n = 3) that received no block (red and green, respectively) or an i.v. anti-TENB2 blocking dose of 10 mg·kg⁻¹ (blue and black, respectively) 24 h before administration of the tracer. Tissue distribution (n = 3) of anti-TENB2-MMAE labelled with ¹²⁵I (C, E) and ¹¹¹In (D, F) in mice from the same four treatment groups was also performed at 24 (C, D) and 72 (E, F) h after radiotracer administration. *P < 0.05 by unpaired t-test.