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. 2012 Dec 20;168(2):488–501. doi: 10.1111/j.1476-5381.2012.02183.x

Figure 8.

Figure 8

PMX205 ameliorates DSS induced body weight loss, colon shortening and histopathological changes in C57BL/6 mice. C57BL/6 mice had 3% DSS added to their water for 5 days. Untreated mice were kept on facility water until day 7. PMX205 or water (control) was administered orally beginning 1 day prior to the DSS start (day 0). PMX205 significantly prevented the (A) body weight and (B) colon shortening due to the DSS exposure. Results are presented as mean ± SEM (n = 5–14 mice per group). (C) Haematoxylin and eosin-stained colons from (a,d) untreated, (b,e) control or (c,f) PMX205-treated group. (D) Inflammation scores, where each dot represents a single mouse and the line represents median score. *P < 0.05 and **P < 0.01.