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The permeability coefficient (Peff, cm/sec) obtained in in-situ rat perfusion study for metoprolol (reference standard), GOCarb and its amino acid prodrugs at 0.1mM. Acyclovir and valacyclovir Peff values (0.01mM) were reported previously.11a Permeability was observed as disappearance of prodrug in perfusate. Data presented as Mean ± SEM, n = 4.
