. Author manuscript; available in PMC: 2014 Feb 4.

Published in final edited form as: Mol Pharm. 2013 Jan 4;10(2):512–522. doi: 10.1021/mp300564v

Table 2.

Pharmacokinetic parameter estimates of GOCarb (GOC) and GOC-L-Valine following oral dosing in fasted and fed mice.

Drug	Dose (mg/kg)	Route	Tmax hrs	Cmax ng/ml	AUC_24hr (ng/mL· hr)
GOC	1	IV	-	-	487 ± 206
GOC	10	po-fasted	1.3 ± 0.6	50.9 ± 35.8	278 ± 52
GOC	10	po-fed	3.0 ± 1.2	65.4 ± 26.8	291 ± 87
GOC-L-Val	1	IV	-	-	641 ± 52
GOC-L-Val	10	po-fasted	2.2 ± 1.1	541.0 ± 226.9	3096 ± 558
GOC-L-Val	10	po-fed	2.4 ± 1.3	405.1 ± 297.3	1442 ± 338