Table 2.

Pathways involving BEAF-32-bound genes down-regulated by transcription changes in cells lacking BEAF-32 in wing imaginal tissue. The classification and analysis is based on gene id and nature of response seen in mutant tissue. The p value (in parenthesis) is calculated based on significant representation of genes with respect to the total number of genes involved in the pathway using the Ingenuity Pathway Analysis program (IPA).

Name of the down regulated pathway	Pathway component, gene name
Protein ubiquitination pathway (1.02E01)	Prosbeta3, Roc1a, Prosbeta5, CG7375, Rpn9, CG7375, Prosalpha7, P58IPK, CG7872, CG12096, CG12096, Rpn2, CG7656, Rpt3, Elongin-C, l(2)05070, Rpn11, Pros54, Rpt1, UbcD2
Hypoxia signaling (3.15E00)	Pdi, CG7375, CG7656, UbcD2, tgo
Mitochondrial dysfunction (2.86E00)	ATPsyn-gamma, ND75, levy, ND23, CG9314, CG17856
Oxidative phosphorylation (2.17E00)	ATPsyn-gamma, ND75, levy, ND23, CG3560
NRF2-mediated oxidative stress response (2.51E00)	Roc1a, Mgstl, CG2852, Hop, Cat, UbcD4, P58IPK
Fatty acid metabolism (2.05E00)	Fdh, CG31075, CG3961, CG3961, CG3415, CG12262, CG4389
Mismatch repair in eukaryotes (1.82E00)	mus209, tos
Aryl hydrocarbon receptor signaling (1.76E00)	cathD, Mgstl, CG31075, Cdk4, Tango9
Nucleotide sugars metabolism (1.73E00)	UGP, CG12030
Wnt/β-catenin signaling (1.45E00)	nmo, gish, CG7115, CkIIbeta-PE, dod
Valine, leucine and isoleucine degradation (1.69E00) tryptophan metabolism (1.4E00) β-alanine metabolism (1.39E00) arginine and proline metabolism (1.35E00)	CG31075, CG3415, CG12262, CG4389 Cat, CG5220 CG12262 Pdi, slgA, SamDC