Table 2.
Evaluation of the mean droplet size in the nanoemulsions A, B, C and D, in the absence of drug (control) and in the presence of the drug incorporated in the oil phase (OP) and in the finished formulation (FF)
| NE | Drug incorporation method | DAP incorporated (%) | Mean droplet size (nm) | SPAN 20 |
|---|---|---|---|---|
| A | Control | – | 9.3 ± 2.2 | 0.6167 |
| OP | 2.0 | 9.6 ± 2.5 | 0.6765 | |
| FF | 2.0 | 11.9 ± 2.3 | 0.5068 | |
| B | Control | – | 9.0 ± 2.3 | 0.6531 |
| OP | 5.0 | 9.0 ± 2.30 | 0.6531 | |
| FF | 5.0 | 8.9 ± 2.3 | 0.7089 | |
| C | Control | – | 11.2 ± 2.1 | 0.4801 |
| OP | 5.0 | 7.5 ± 1.7 | 0.6245 | |
| FF | 5.0 | 9.9 ± 2.7 | 0.7195 | |
| D | Control | – | 10.0 ± 2.3 | 0.5998 |
| OP | 5.0 | 9.0 ± 2.8 | 0.8288 | |
| FF | 5.0 | 8.7 ± 2.4 | 0.7194 |
Notes: Mean ± standard deviation; n = 3.
Abbreviations: DAP, dapsone; NE, nanoemulsion.