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. Author manuscript; available in PMC: 2013 Feb 14.
Published in final edited form as: Am J Transplant. 2008 Oct 31;9(1):74–82. doi: 10.1111/j.1600-6143.2008.02463.x

Figure 1. Nox-2 and p22phox increased in tubular epithelial cells in human allografts.

Figure 1

We performed double-staining immunofluorescence studies in kidney allografts with IFTANOS compared to control native kidneys. In the control kidney, few interstitial cells stained for Nox-2 and p22phox. The molecules costained, suggesting a functional role for Nox. Kidney allografts showed significantly greater interstitial staining for both molecules. In addition, tubular epithelial cells upregulated Nox in areas of injury, suggestive of increased ROS generation by renal tubules.