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. Author manuscript; available in PMC: 2013 Feb 14.
Published in final edited form as: Am J Transplant. 2008 Oct 31;9(1):74–82. doi: 10.1111/j.1600-6143.2008.02463.x

Figure 3. Myofibroblasts but not mature fibroblasts expressed Nox-2.

Figure 3

Double-staining immunofluorescence studies were performed using α-SMA (myofibroblasts) S100A4 (fibroblasts) and Nox-2 antibodies. Some tubular cells expressed α-SMA or S100A4 suggestive of EMT (B and E). Tubular and interstitial cells expressing S100A4 did not costain for Nox-2 (A–C). However, the large majority of α-SMA+ interstitial (I) and tubular (T) cells were also positive for Nox-2 (D–E). These studies suggest that myofibroblasts but not mature fibroblasts are a source of Nox-2 in the allograft.