TABLE 3.
Subscale scores of MINI-MAC in relation to time and 5-HTTLPR genotype
| Allelic variants | T0 mean±SEM | T1 mean±SEM | T2 mean±SEM | Effect of Time pa | Effect of genotype pb | |
|---|---|---|---|---|---|---|
| Hopelessness-Helplessness | S/S-S/L-L/L | 11.94±0.58 (N=48) | 11.67±0.53 (N=48) | 11.06±0.64 (N=35) | .581 | .692 |
| S/S-S/L | 11.86±0.71 (N=29) | 11.62±0.72 (N=29) | 11.63±1.06 (N=19) | .969 | ||
| L/L | 12.05±1.01 (N=19) | 11.74±0.78 (N=19) | 10.38±0.61 (N=16) | .353 | ||
| Fighting spirit | S/S-S/L-L/L | 14.17±0.37 (N=48) | 14.25±0.28 (N=48) | 14.20±0.47 (N=35) | .986 | .455 |
| S/S-S/L | 14.17±0.40 (N=29) | 14.28±0.32 (N=29) | 14.68±0.57 (N=19) | .698 | ||
| L/L | 14.16±0.71 (N=19) | 14.21±0.52 (N=19) | 13.63±0.78 (N=16) | .803 | ||
| Fatalism | S/S-S/L-L/L | 9.35±0.35 (N=48) | 9.04±0.32 (N=48) | 8.94±0.31 (N=35) | .663 | .520 |
| S/S-S/L | 9.14±0.43 (N=29) | 8.97±0.43 (N=29) | 8.95±0.44 (N=19) | .942 | ||
| L/L | 9.68±0.61 (N=19) | 9.16±0.49 (N=19) | 8.94±0.44 (N=16) | .595 | ||
| Anxious preoccupation | S/S-S/L-L/L | 15.71±0.70 (N=48) | 13.50±0.65 (N=48) | 12.51±0.67 (N=35) | .004 | .023 |
| S/S-S/L | 16.31±0.96 (N=29) | 13.72±0.86 (N=29) | 14.21±0.96 (N=19) | .102 | ||
| L/L | 14.79±0.99 (N=19) | 13.16±1.00 (N=19) | 10.50±0.66 (N=16) | .008 | ||
| Avoidance | S/S-S/L-L/L | 10.79±0.47 (N=48) | 9.50±0.41 (N=48) | 9.43±0.44 (N=35) | .048 | .698 |
| S/S-S/L | 11.00±0.65 (N=29) | 9.31±0.53 (N=29) | 9.68±0.65 (N=19) | .105 | ||
| L/L | 10.47±0.65 (N=19) | 9.79±0.66 (N=19) | 9.13±0.60 (N=16) | .352 |
The data reported are the mean±SEM of the psychometric scores at recruitment (T0), after one month (T1) and three months (T2)
The data were analyzed with the analysis of variance (ANOVA), testing the effect of timea and of genetic polymorphismb as independent variables; statistical significance was set at p<0.05 level