Fig. 1.

Conservation of the mAb 697 epitope in the V2 of pseudotyped viruses tested in the neutralization assay. Sequence logo was created by alignment of 41 V2 sequences from Table 5 using http://weblogo.berkeley.edu. The logo consists of stacks of letters for each position in the sequence. The overall height of the stack indicates the sequence conservation at that position, while the height of letter within the stack indicates the relative frequency of each amino acid at that position. The highly conserved V2 N- and C-terminal cysteines are not shown. The V2 residues in highlighted boxes are targeted by V2-specific mAb 697. The hypervariable region is in area spanning positions 28 to 45. Amino acids are colored according to their chemical properties: basic amino acids (K,R,H) are blue, acidic amino acids (D,E) are red, hydrophobic amino acids (A,V,L,I,P,W,F,M) are black and polar amino acids (G,S,T,Y,C,Q,N) are green.