Table 2.
Effect of interaction of XRCC1 399 polymorphism with vinylchloride (VC) exposure on p53 biomarker.
|
XRCC1 genotype |
VC exposure (ppm-years) |
p53 Biomarker |
Crude OR |
Adjusted ORa |
|||
|---|---|---|---|---|---|---|---|
| − | + | OR | 95% CI | OR | 95% CI | ||
| Arg-Arg | <1706 | 48 | 18 | 1.0 | 1.0 | ||
| 1706–5704 | 48 | 15 | 0.8 | 0.4–1.7 | 1.1 | 0.5–2.4 | |
| >5704 | 50 | 23 | 1.2 | 0.6–2.6 | 1.8 | 0.8–3.8 | |
| Arg-Gln | <1706 | 67 | 21 | 0.8 | 0.4–1.7 | 0.8 | 0.4–1.7 |
| 1706–5704 | 66 | 32 | 1.3 | 0.7–2.6 | 1.6 | 0.8–3.2 | |
| >5704 | 47 | 31 | 1.8 | 0.9–3.6 | 2.8 | 1.3–6.2 | |
| Gln-Gln | <1706 | 17 | 8 | 1.2 | 0.5–3.4 | 1.3 | 0.5–3.5 |
| 1706–5704 | 13 | 12 | 2.5 | 1.0–6.3 | 3.3 | 1.2–8.5 | |
| >5704 | 18 | 12 | 1.8 | 0.7–4.4 | 3.1 | 1.2–82 | |
a
Adjusted for age, smoking and drinking; p for trend = 0.002.