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Association between ERCC2/XPD 312 and 751 polymorphisms and p53 biomarker in vinylchloride (VC) workers.
|
ERCC2/XPD genotype |
p53 Biomarker |
Crude OR |
Adjusted ORa |
|||
|---|---|---|---|---|---|---|
| − | + | OR | 95% CI | OR | 95% CI | |
| 312 Asp-Asp | 159 | 64 | 1.0 | 1.0 | ||
| Asp-Asn | 179 | 81 | 1.1 | 0.8–1.7 | 1.2 | 0.8–1.7 |
| Asn-Asn | 36 | 27 | 1.9 | 1.1–3.3 | 1.9 | 1.0–3.4 |
| 751 Lys-Lys | 155 | 67 | 1.0 | 1.0 | ||
| Lys-Gln | 179 | 77 | 1.0 | 0.7–1.5 | 1.0 | 0.7–1.6 |
| Gln-Gln | 40 | 28 | 1.6 | 0.9–2.8 | 1.6 | 0.9–2.9 |
Adjusted for age, smoking, drinking and cumulative VC exposure; p for trend >0.05.
