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Association between ERCC2/XPD 312 and 751 polymorphisms and p21 biomarker in vinylchloride (VC) workers.
|
ERCC2/XPD genotype |
p21 Biomarker |
Crude OR |
Adjusted ORa |
|||
|---|---|---|---|---|---|---|
| − | + | OR | 95% CI | OR | 95% CI | |
| 312 Asp-Asp | 172 | 51 | 1.0 | 1.0 | ||
| Asp-Asn | 169 | 91 | 1.8 | 1.2–2.7 | 1.8 | 1.2–2.7 |
| Asn-Asn | 34 | 29 | 2.9 | 1.6–5.1 | 3.0 | 1.6–5.4 |
| 751 Lys-Lys | 169 | 53 | 1.0 | 1.0 | ||
| Lys-Gln | 168 | 88 | 1.7 | 1.1–2.5 | 1.6 | 1.1–2.5 |
| Gln-Gln | 38 | 30 | 2.5 | 1.4–4.4 | 2.6 | 1.5–4.6 |
Adjusted for age, smoking, drinking and cumulative VC exposure; p for trend <0.0006.
