Table 5.

Effect of interaction of ERCC2/XPD 312 and 751 polymorphisms with vinylchloride (VC) exposure on p21 biomarker in VC workers.

ERCC2/XPD genotype	VC exposure (ppm-years)	P21 Biomarker		Crude OR		Adjusted ORa
		−	+	OR	95% CI	OR	95% CI
312 Asp-Asp	<1706	59	15	1.0		1.0
	1706–5704	69	8	0.5	0.2–1.1	0.5	0.2–1.2
	>5704	44	28	2.5	1.2–5.2	2.6	1.2–5.7
Asp-Asn	<1706	63	21	1.3	0.6–2.8	1.3	0.6–2.7
	1706–5704	52	35	2.7	1.3–5.3	2.7	1.3–5.7
	>5704	54	35	2.6	1.3–5.1	2.7	1.3–5.8
Asn-Asn	<1706	13	8	2.4	0.9–6.8	2.4	0.8–6.9
	1706–5704	11	11	3.9	1.5–10.5	4.1	1.5–11.3
	>5704	10	10	3.9	1.4–10.8	4.1	1.4–11.8
751 Lys-Lys	<1706	67	14	1.0		1.0
	1706–5704	60	11	0.9	0.4–2.1	0.9	0.4–2.1
	>5704	42	28	3.2	1.5–6.7	3.3	1.5–7.1
Lys-Gln	<1706	51	25	2.4	1.1–4.9	2.3	1.1–4.9
	1706–5704	58	32	2.6	1.3–5.4	2.7	1.3–5.6
	>5704	59	31	2.5	1.2–5.1	2.5	1.2–5.5
Gln-Gln	<1706	17	5	1.4	0.4–4.5	1.4	0.4–4.4
	1706–5704	14	11	3.8	1.5–9.7	3.8	1.4–10.4
	>5704	7	14	9.6	3.6–25.7	9.7	3.2–29.0

^aAdjusted for age, smoking and drinking; p for trend <0.0001.