Figure 6.
Fate mapping of NG2 glial cells late during disease in SOD1G93A mice. (A) PDGFRa-YFP-SOD1G93A mice were treated with tamoxifen at post-natal Day 120 (P120) and YFP expression was evaluated at post-natal Day 140 (P140). (B–G) At post-natal Day 140, oligodendrocytes that had newly differentiated at the symptomatic disease stage could be detected throughout the spinal cord. Many of the newly generated oligodendrocytes were enlarged and were dysmorphic (arrows), n = 3. Few oligodendrocytes had a normal appearance (arrowheads). Enlarged confocal images are shown in (E–G). Scale bars: B–G = 50 µm.