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. 2012 Nov 7;5(2):440–446. doi: 10.3892/ol.2012.1017

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Copyright © 2013, Spandidos Publications

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Figure 7. — Effects of sorafenib and gemcitabine alone and in the sequential exposure schedules for 72 h on the expression levels of upstream and downstream signaling pathways in (A) A549 and (B) PC-9 cells were evaluated by western blot analysis. Gem (gemcitabine), Sor (sorafenib) and sequential exposures of Sor→Gem (sorafenib followed by gemcitabine) and Gem→Sor (gemcitabine followed by sorafenib) affected the expression levels of molecules in upstream and downstream signaling pathways. ERK, extracellular signal-regulated kinase; PDGFR, platelet-derived growth factor receptor.