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. 2013 Feb 14;8(2):e56083. doi: 10.1371/journal.pone.0056083

Figure 4. 17-AAG inhibits tumor metastasis in a luciferase metastatic pheochromocytoma model.

Figure 4

A) Efficacy of 17-AAG in an MTT-luc experimental (tail vein) metastasis model. Representative images of animals (n = 6) treated three times a week with 17-AAG over a period of 5 weeks and a control group treated with vehicle alone. B) Quantification of metastatic tumor growth as determined by luciferase measurement in an IVIS instrument. Data are plotted as mean photon counts (total flux) from regions of interest (ROI). Error bars represent standard deviations. C) 17-AAG increases Hsp70 plasma levels in vivo (p = 0.035). D) Kaplan-Meier survival analysis: outcome as survival time was graphed and analyzed for statistical significance using GraphPad; control (vehicle alone; black line) and 17-AAG treated animal (red line) are represented as a function of percent survival. Using a log-rank (Mantel-Cox) test the two groups were statistically different at p<0.0001.